
From Click to Crisis: How Typosquatting Targets German Businesses Online
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C3 glomerulopathy (C3G) is characterized by the buildup of C3 and its fragments within the kidney's glomeruli, leading to inflammation and potential kidney damage. This condition, similar to paroxysmal nocturnal hemoglobinuria (PNH), stems from a dysregulation of the alternative complement pathway in the immune system. Patients typically exhibit symptoms such as hematuria, proteinuria, and hypertension. Alarmingly, around 50% of individuals diagnosed with C3G may experience kidney failure within a decade, necessitating lifelong dialysis or even kidney transplantation.
Currently, there are no approved targeted treatments for C3G. However, this situation may soon change with Iptacopan, an oral Factor B inhibitor that has been under investigation for complement-mediated disorders, including both PNH and C3G. Iptacopan was introduced to the German market for PNH treatment in autumn 2024.
The European Commission is now evaluating a new recommendation from experts at the European Medicines Agency (EMA) regarding the use of Iptacopan for adult patients with C3G. The recommendation suggests that Iptacopan could be administered in conjunction with a Renin-Angiotensin-System (RAS) inhibitor, or as an alternative for patients who cannot tolerate RAS inhibitors or for whom these inhibitors are contraindicated.
This recommendation is based on findings from the APPEAR-C3G study, which demonstrated that patients receiving Iptacopan alongside supportive therapy experienced a significant reduction in proteinuria, as well as stabilization and numerical improvement in their estimated glomerular filtration rate (eGFR). The European Commission is expected to announce its decision regarding the approval within 67 days.
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Health Insurance in Germany is compulsory and sometimes complicated, not to mention expensive. As an expat, you are required to navigate this landscape within weeks of arriving, so check our FAQ on PKV. For our guide on resources and access to agents who can give you a competitive quote, try our PKV Cost comparison tool.
Germany is famous for its medical expertise and extensive number of hospitals and clinics. See this comprehensive directory of hospitals and clinics across the country, complete with links to their websites, addresses, contact info, and specializations/services.
Join us for an exquisite evening of classical music featuring the Bayerisches Rundfunk Symphony Orchestra. Conducted by Daniel Harding, with Emiko Yuasa on viola and Steven Isserlis on cello, the program includes:
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