New Research Highlights Potential of Vitamin B1 Derivative in Enhancing Alertness

Recent findings from researchers at the University of Tsukuba have brought to light the effects of thiamine tetrahydrofurfuryl disulfide (TTFD), a modified form of vitamin B1. This derivative is noted for its ability to promote wakefulness and increase motivation for physical activity.

The study, published in The Journal of Physiological Sciences, addresses the longstanding issue of thiamine deficiency, which has historically led to various health problems, notably beriberi, particularly prevalent during Japan's Edo to Meiji periods (1868-1912). The introduction of thiamine derivatives in the 1950s marked a significant advancement in addressing these nutritional deficiencies.

Even in contemporary society, where thiamine deficiency is less common, these derivatives are widely used as supplements to boost daily energy levels. Recent investigations have begun to explore the potential cognitive benefits of thiamine derivatives.

In previous research, the team discovered that TTFD elevates dopamine levels in the medial prefrontal cortex of rats, correlating with increased physical activity. This dopamine surge is associated with the activation of brain regions pertinent to arousal, including the ventral tegmental area and the locus coeruleus. Building on these results, the research team postulated that administering TTFD would enhance arousal.

To validate this hypothesis, the researchers administered TTFD intraperitoneally to a group of rats and monitored alterations in their sleep-wake patterns and physical activity using electroencephalography (EEG) and electromyography. The findings indicated a notable enhancement in both physical activity and wakefulness following TTFD administration.

Future research endeavors aim to delve deeper into the neural mechanisms that underpin these effects, with the potential of highlighting TTFD's role in improving daily vitality.

For more detailed information, refer to the study: Toshiaki Hata et al, "Promoting arousal associated with physical activity with the vitamin B1 derivative TTFD," The Journal of Physiological Sciences (2025).