Nationwide Surge in Obesity-Related Cancer Deaths Over Two Decades

Mon 14th Jul, 2025

Recent findings indicate a significant increase in cancer deaths associated with obesity across the United States, with rates tripling over the past twenty years. This alarming trend was unveiled during the Endocrine Society's annual meeting in San Francisco, where research highlighted the impact of obesity on cancer mortality.

The comprehensive study analyzed data from over 33,000 fatalities linked to cancers exacerbated by obesity. Researchers observed particularly pronounced increases among specific demographics, including women, older adults, and minority groups such as Native Americans and Black Americans.

According to the lead researcher from Hackensack Meridian Jersey Shore University Medical Center, the findings underscore obesity as a critical risk factor contributing to various cancers, leading to substantial mortality rates. The study calls for targeted public health initiatives aimed at early cancer detection and improved healthcare access, especially for populations in rural and underserved regions.

Obesity remains a prevalent health issue in the U.S., with approximately 40.3% of adults classified as obese according to the Centers for Disease Control and Prevention (CDC). This complex condition arises from a combination of genetic, physiological, hormonal, environmental, and developmental influences.

In addition to increasing cancer risk, obesity is also linked to several serious chronic diseases, including hypertension, high cholesterol, prediabetes, type 2 diabetes, heart disease, and kidney disease. The CDC identifies 13 specific types of cancer associated with obesity, which collectively account for 40% of all cancer diagnoses in the country.

  • Adenocarcinoma of the esophagus
  • Breast cancer (postmenopausal women)
  • Colon and rectal cancer
  • Uterine cancer
  • Gallbladder cancer
  • Upper stomach cancer
  • Kidney cancer
  • Liver cancer
  • Ovarian cancer
  • Pancreatic cancer
  • Thyroid cancer
  • Meningioma (a type of brain cancer)
  • Multiple myeloma

The study utilized mortality data from the CDC, revealing that age-adjusted mortality rates from obesity-associated cancers rose significantly from 3.73 to 13.52 per million over the two-decade span. The most considerable increases were noted in women, older adults, and specific racial and ethnic groups, alongside rural populations.

Regionally, the Midwest was found to have the highest rates of obesity-related cancer deaths, while the Northeast reported the lowest. A closer look at individual states showed that Vermont, Minnesota, and Oklahoma had the highest mortality rates linked to obesity-related cancers, in stark contrast to Utah, Alabama, and Virginia, which recorded the lowest rates.


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