Only Three Nights of Poor Sleep May Increase Heart Disease Risk, Study Finds

Mon 26th May, 2025

Recent research from Uppsala University in Sweden indicates that just three nights of inadequate sleep can adversely affect heart health. The study reveals that sleeping for merely four hours a night can lead to changes in blood chemistry associated with a heightened risk of heart disease.

The research focused on inflammatory proteins present in the bloodstream, which are produced by the body in response to stress or illness. Prolonged elevation of these proteins can damage blood vessels and increase the likelihood of developing serious cardiovascular issues, including heart failure, coronary heart disease, and atrial fibrillation.

The study involved a controlled experiment with 16 healthy young men who participated in two separate routines: one involving three nights of normal sleep (approximately 8.5 hours) and the other consisting of three nights of sleep restriction (around 4.25 hours). After each sleep phase, participants underwent a short, high-intensity cycling workout, and their blood was analyzed both before and after these sessions.

Researchers measured nearly 90 different proteins in the blood samples. The findings showed a significant increase in inflammatory markers linked to heart disease following sleep deprivation. Typically, exercise is known to enhance levels of beneficial proteins such as interleukin-6 and BDNF, which support brain and heart health; however, these beneficial responses were diminished after poor sleep.

Alarmingly, these physiological changes were observed even in young, healthy individuals after only a few nights of poor sleep. This is particularly concerning given that many adults experience sleep disturbances periodically, and approximately one in four individuals work shifts that disrupt their sleep patterns.

The timing of blood collection also impacted protein levels, with significant variations observed between morning and evening samples, especially following sleep restriction. This indicates that not only does sleep influence the composition of the blood, but it also affects when these changes become detectable.

In a world where productivity often takes precedence over sufficient rest, this study serves as a crucial reminder of the importance of sleep for cardiovascular health. As many individuals prioritize work, social engagements, or screen time over sleep, the biochemical consequences can be profound and lasting.

Overall, the findings underscore the necessity of adequate sleep for maintaining not only heart health but overall well-being. With increasing awareness of the detrimental effects of sleep deprivation, it is essential for individuals to recognize the value of rest in their daily lives.


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