New Research Explores Gender-Based Differences in Nutritional Digestion

Sat 12th Jul, 2025

A groundbreaking study from the Technion--Israel Institute of Technology has unveiled significant variances in the digestive processes of men and women, particularly regarding the consumption of milk and plant-based milk alternatives. These findings, published in the journal Food Research International, suggest that dietary recommendations could benefit from being tailored to account for gender differences in digestion.

The research, spearheaded by a team including Professor Uri Lesmes and several graduate students, aimed to investigate whether the nutritional advantages derived from various food sources differ between sexes. The team developed a specialized digestion model to simulate the digestive systems of males and females, revealing notably distinct results.

The model indicated that men exhibited a more efficient breakdown of milk proteins. In stark contrast, women showed superior digestion of oat-based plant milk. This divergence in digestive efficiency raises intriguing questions about the historical dietary roles of men and women, suggesting that evolutionary factors may have influenced these differences.

Professor Lesmes noted that the study aligns with anthropological insights into early human dietary patterns, where men were primarily hunters and women gatherers. This division of labor not only shaped food acquisition but may have also led to differing digestive adaptations, with men evolving to digest animal proteins more effectively.

Further investigation into the digestion process revealed variations in the types of peptides and amino acids produced. In male subjects, higher concentrations of antimicrobial peptides were detected, while female subjects had increased levels of osteoanabolic peptides, which are linked to bone health. This finding is particularly relevant given the prevalence of osteoporosis among women, suggesting that plant-based protein sources may offer unique health benefits.

The study concludes that biological sex plays a crucial role in digestion and nutrition, advocating for the integration of these findings into future nutritional policies and food engineering. The implications of this research could pave the way for more personalized dietary recommendations that take gender into account, ultimately enhancing health and nutrition for all.

As the demand for plant-based diets continues to rise, understanding how different demographics respond to these diets will be vital in crafting effective nutritional strategies. The research team emphasizes the need for a future in food science that is informed by scientific research and focused on health outcomes.

For more insights, refer to the original study by Leehen Mashiah et al in Food Research International.


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