Genetic variants influence migraine risk
LMU (Ludwig-Maximilians-Universität) researchers have for the first time identified four genes linked to the most common form of migraines. Together with their colleagues from the International Headache Genetics Consortium, the Munich researchers have mapped four genetic risk factors in migraine patients to chromosomes 1, 3, 6 and 9.
The new markers are rela
Statistical associations
"We compared genetic data from nearly 5000 migraine patients and over 7,000 controls," says Dichgans. The objective was to identify among the millions of polymorphisms those variants that are statistically overrepresented in the patient population.
"Our findings are a major step in the unravelling of the molecular pathways of migraine", says Freilinger. "The identified variants seem to point to brain hyperexcitability and vascular dysfunction as important mechanisms".
A different risk factor was previously identified in patients suffering from migraine with aura. In that study, the results implied that an excess of glutamate, a neurotransmitter, at synapses (contact sites between nerve cells) predisposed to the condition. Freilinger is confident that work on larger patient populations will pinpoint further risk factors. Source: LMU