Detector of DNA damage: Structure of a repair factor revealed

Ultraviolet and other types of radiation can damage DNA in the form of DNA strand breaksThere are various types of damage to DNA, and DNA strand breaks are one of them, involving a cut in one or both DNA strands. Double-strand breaks in cellular DNA are especially dangerous and can trigger tumorigenesis, the process involved in the production of a new tumor or tumors.

Researchers from The Ludwig Maximilian University of Munich (LMU) have now determined the structure of a protein involved in the repair and signaling of DNA double-strand breaks. The work throws new light on the origins of neurodegenerative diseases and certain tumor types.

Agents such as radiation or environmental toxins can cause double-stranded breaks in genomic DNA, which facilitate the development of tumors or the neurodegenerative disorders ataxia telangiectasia (AT) and AT-like disease (ATLD). Hence efficient repair mechanisms are essential for cell survival and function. The so-called MRN complex is an important component of one such system, and its structure has just been elucidated by a team led by Professor Karl-Peter Hopfner of LMU's Gene Center.

German Engineering Jobs
Write a comment ...
Post comment