Link Between Gynecological Disorders and Increased Cardiovascular Risk Identified

Recent research highlights a concerning association between nonmalignant gynecological diseases (NMGD) and an elevated risk of cardiovascular and cerebrovascular diseases (C/CVD). A systematic review and meta-analysis published in the journal Heart sheds light on this critical health issue.

The study, conducted by a team from the Ospedale Regionale di Lugano in Switzerland, sought to understand the relationship between NMGD and C/CVD. The researchers defined a composite outcome for C/CVD, which included conditions such as ischemic heart disease, cerebrovascular disease, heart failure, and peripheral vascular disease.

Analyzing data from 28 studies encompassing over 3.2 million participants, the findings indicated that more than half of the studies exhibited a significant risk of bias. Notably, individuals diagnosed with NMGD showed a markedly increased risk of developing composite C/CVD, with a summary relative risk (SRR) of 1.28. The risks for specific components were even more alarming: ischemic heart disease had an SRR of 1.41, while cerebrovascular disease presented an SRR of 1.33.

Among those with specific conditions such as endometriosis or polycystic ovary syndrome, the risk of C/CVD was further pronounced. These findings emphasize the importance for healthcare providers to recognize the potential links between gynecological disorders and cardiovascular health. This awareness can play a pivotal role in informing clinical practices aimed at reducing the risk of C/CVD in affected individuals.

The authors of the study noted the necessity for additional longitudinal research to explore the risks associated with C/CVD outcomes among various subpopulations with NMGD. Such studies could pave the way for effective primary prevention strategies.

It is also essential to mention that some authors of the study have disclosed affiliations with the pharmaceutical industry, which underscores the need for transparency in health-related research.

For more detailed insights, the full study can be referenced: Giorgia Elisabeth Colombo et al, "Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis," Heart (2025).